Assisted Hatching

In the world of assisted reproductive technology, in vitro fertilization (IVF) has become a widely used method for couples struggling with infertility. However, despite its success rates, IVF may not always guarantee a successful pregnancy. This is where techniques like assisted hatching come into play.

Assisted hatching is a procedure that is sometimes recommended as an additional step during the IVF process. It involves creating a small hole or thinning the outer shell of the embryo, known as the zona pellucida, to facilitate the embryo’s implantation into the uterus. This procedure can increase the chances of a successful pregnancy, particularly in certain cases.

Why is Assisted Hatching Performed?

Assisted hatching is primarily recommended for couples who have experienced repeated IVF failures or for those who have poor embryo quality. It is believed that a thick or hardened zona pellucida can hinder the embryo’s ability to break free and implant itself into the uterine lining.

Additionally, women over the age of 35, as well as those with elevated follicle-stimulating hormone (FSH) levels or a history of previous failed IVF cycles, may also benefit from assisted hatching. By thinning the zona pellucida, the embryo has an increased chance of successfully attaching to the uterine wall, leading to a successful pregnancy.

The Assisted Hatching Procedure

Assisted hatching is typically performed on day three of embryo development, just before the embryos are transferred into the uterus. The procedure can be carried out using different techniques, including mechanical, chemical, or laser-assisted methods. The choice of technique depends on the clinic’s expertise and equipment availability.

Mechanical methods involve the use of a small needle or forceps to create a small hole or scratch on the zona pellucida. Chemical methods involve the application of a diluted acid solution to weaken the outer shell. Laser-assisted methods, on the other hand, use a laser beam to precisely thin the zona pellucida.

Precautions and Risks

While assisted hatching can improve the chances of successful implantation, it is essential to consider the potential risks associated with the procedure. The most common risks include damage to the embryo during the process, as well as an increased risk of monozygotic (identical) twinning. The latter occurs when the embryo splits into two separate embryos, resulting in a higher chance of complications during pregnancy.

It is crucial to discuss the risks and benefits of assisted hatching with your fertility specialist. They will assess your specific situation and determine whether this procedure is suitable for you.


Assisted hatching is a technique that can enhance the success rates of IVF for couples struggling with infertility. Thinning the outer shell of the embryo facilitates the implantation process and increases the chances of a successful pregnancy. However, it is important to note that assisted hatching is not recommended for everyone and should be discussed with a fertility specialist based on individual circumstances.

If you are undergoing IVF and have experienced multiple failures or have poor embryo quality, consulting with your doctor about the possibility of assisted hatching may be beneficial. They can guide you through the process and provide the necessary information to make an informed decision about your fertility journey.